I finally jumped on this today for PIT-IST over Thanksgiving. We have a connection through ORD on the way out, and JFK on the way back. There's a nice discount on children's fares, so it was around $650 for the adults, and $570 for the children - not bad.
This trip will take my husband and son over the line for *G on UA, which is nice, and put me between PP and 1K. We love Turkey, and haven't been back for a few years, so this all works out very nicely.