MA - the US-only flights may seem boring, but going to a far-off country on business is definitely NOT a holiday - Lagos (for any reason) & (doing business in) Russia??? No thank you! (Houston's okay, I guess, as you can get Blue Bell there)
In the space of 6 months I used up 25 passport pages, & had to start telling my boss that I would only go to countries I already held visas for, as my new passport was taking a while to work its way through the system. Try telling a immigration agent who (deliberately) doesn't speak English that the Post-It note over the sole remaining blank page in your passport is there for a reason (I was saving it for the US visa allowing me to live here)
Short trips are okay (eg jetting around Europe), but when you start spending more nights aboard aircraft than in bed it gets a little wearying - MF flies across the Atlantic twice a week ALL THE TIME. Imagine the jetlag!
The only advantage I can think of is all the duty free alcohol - and you can have too much of even that after a while: there's only so much Scotch you can consume/give away.