I got one of these about 18 months ago, absolutely love it.
Holding it in front of me, the large outer pocket on the left carries a couple of pens in the holders, my keys on the clip, normally in the zipper pocket. Emergency stash of business cards goes into the holder in there; other odds and sods go into the pocket (memory sticks, magnifiers (I need them for work) and a couple of flashlights (inova x5 UV for work, standard one for use in the dark). The smaller zip pocket below this holds passport, vaccination certificates, some cash, more business cards, pills (ibuprofen and imodium). the tall pocket on the front right normally has spectacles and sunglasses and a couple of pairs of disposable contact lenses (I wear these all the time, these are emergency stash). The zipper pocket below carries wallet when I go through security and on the plane.
The sheath pocket between the outer and main sections gets used for on-the-go drop storage: boarding passes, pocket stuff when going through x-ray, old receipts, etc. Main compartment gets my notebook (larger than a4 size moleskine style book), work papers, iPad in a waterfield case and my entertainment pouch (again from waterfield) that carries iems, amp, iPod, a few other USB cables. The laptop pocket at the back has, you guessed it, laptop and the cable pouch that came with the wallet sits on top of the laptop. It carries the charger, a charger for the iPod, cufflinks, collar stiffeners, other small bits and pieces. Bag is pretty heavy with all of that in it, but it works!