AS others have said, you can definitely make a one day trip to the Galilee. Whether you can see what you want to--is impossible to know without your sharing what you want to see.

BTW two weeks ago I had a friend who was a first time visitor to Israel visiting me. We drove in an Eldan car ( 2 women) from Jerusalem to Masada--piece of cake. --only thing which is potentially tricky is getting out of Jerusalem.