MHO is to save it for Maui Kea Lani as San Francisco is such an excellent dining city there are so many outstanding restaurants to sample within such a short distance to the Fairmont on Nob Hill.
Italian in North Beach, Chinatown, seafood at the Marina with it's stunning bay views, the Mission and Russian Hill all offer memorable meals and distinct experiences to each neighborhood.
Sheesh I probably sound like someone from the tourist bureau but IMHO San Francisco is an often overlook culinary capital most definately worth exploring.