I must admit, the bedbug risk freaks me out a bit and my current practice is to check for bedbug reports before staying at any hotel. If I find a report, I don't stay there. It has been surprisingly difficult to find a moderate-high end Marriott, Hilton or Starwood property in SFO without reported incidents.
I realize that many hotels have had isolated problems. I also realize that the fact that hotel has never had a report doesn't guarantee that it's bedbug-free today. Eventually, I'm going to have to stay at a hotel that has had a reported incident (or more than one) and it's likely, given how often I travel, that I'm going to end up "encountering" the little critters. (And if that happens, I plan to throw everything out except the clothes on my back - and then strip down and walk naked into my house.)
But until every hotel I'd want to stay at has a bedbug report, I'm still planning to choose the ones that are incident-free.