My husband and I almost always choose two aisle seats on short flights. Under 4 hours or so. We both like the comfort and flexibility of getting up without crawling over someone and I don't want to sit in the middle. We don't engage in loud conversation across the aisle and use the time to catch up on reading newspapers or in my case to enjoy music. On longer flights or when we are in a premium cabin I compromise and sit in the window seat He is left handed and with a separate glass or scotch and soda it just works out better for all concerned. Whatever works.