Brian,
to give more concrete advice going beyond the already good points others have mentioned it would be necessary to know what "other bag(s)" you carry and your mode of travel as well as your degree of fitness.
When it comes to bags without wheels, they get heavy quickly. When you carry two shoulder bags of more than 10lbs each which would probably be the minimum for a briefcase plus a clothes bag, it is not a very comfortable way of traveling. Not to mention that shoulder straps kill shoulder pads. When the shoulder pads are dead, the suit is dead - or at least it looks like dead.
If you can tell us those things including your all-over packing list, we can give you some advice on an integrated luggage concept that takes all these things into consideration and give you pointers on what luggage to use and how to pack it.
Till