When airlines mention that you need 50K miles to go to Europe for instance does that mean it has to be from their internation hub or can it be from anywhere in the US where that airlines flies.
As an example,if I want to go to Brussels, and I'm in Roanoke (that's in Virginia for you west coasters

)would 50K miles be enough on United, or would United allow the 50K only from Dulles to Brussels.