Go after April for a Thursday to Sunday trip if you can. There is a Thursday evening event called Thursday in the Square or T.I.T.S. as my friends and I called it in college. It's a free concert with beer and food carts and after you stumble to the many bars and restaurants. Take a friend if you can as it will help. Buffalo has many Colleges and Universities beyond its own native population so younger crowds are easy to find. I had a great time there in college and still do when I visit friends. Architecturally they have a huge range. From massive Pierce Arrow Auto building & Museum to Frank Lloyd Wright houses and more. Food...yeah they've got a lot of it and it's all unhealthy and delicious. The area is actually not what you imagine fiscally. The city isn't doing as well as the suburbs but the Buffalo Metro Area is doing well thanks to Health/Science/Pharmaceutical companies being there.

If you do choose to go PM me and I can give you a list of local spots you should try not to miss.