I like the Route 90 route myself, obviously the "northern" section
up my Masada is more interesting. I also like to stop at the Ahava
factory.
I want to mention the rest stop on 90 that features what couldeasily be a stop in Mexico. The animals wandering around were a cool touch.
The western route used to be my favorite, driving up from Eilat, but it is very close to the border, and well............
I confess to one irregularity that I always do, because I can. If you take Route 1 down from Jerusalem and turn right onto Route 90, there is a gas station on the corner. I love being able to fill up my tank while drinking down an ice cold Corona. Ask the guy behind the counter to dig you out the coldest one he has. ahhhhhhhhhhhhhhhh!