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Originally Posted by benzemalyonnais
AC awards will have higher fees (or very high?) than the other option I proposed, and you will have difficulty obtaining 75k without a big big AMEX bonus.
It doesn't matter where you leave from as all awards are priced from USA-Destination, however availability will be a key factor. You might need to pay a little bit for a positioning flight dependent if the alliance has award availability for your desired dates. Shouldn't be a problem though.
It is not correct to say that all awards are priced from USA to destination. While that is true of many programs, it is not true of all. In particular, it is not true of BA's program, which is distance based, and charges separately for each segment flown.