Welcome to FT.
Piece of advice #1 is figure out which airline/alliance you can steer your business toward, most likely to hit top tier if you can do so. With the amount of flying you're doing, there's no excuse for not getting out of coach more often!
Of course the folks here will have plenty of advice! just let us know anything you'd like to share- whether you're forced to fly on certain carriers, whether you have any "loyalties" to certain carriers, etc.
Given the amount of flying you're doing, I'm sure you have plenty to contribute off the bat! Don't be shy, and dive into the forums of the airlines/programs/interests which appeal most to you.