..My concern is that row 27 is way too close to the plane's tail and I dont know if the noise/vibration levels can be slightly higher than in the front but I dont know if that would be a big difference..
Not an issue on LH as they make a major effort to avoid bumpy routes (on SQ, I'd always try to sit over the wing as they navigate from thunderstorm to thunderstorm).
The cabin noise is slightly higher but you will appreciate this as the 380 is so quiet that you can hear all kind of bodily noises from your fellow primates ... the only 380 drawback, I must hasten to add.