The single worst thing that has ever happened to me at a hotel was at the Marriott Warner Center in the L.A. area. Don't blame the hotel -- management was as disturbed about this as I was! It's really a good place.
My ex and I (still married then) checked into the hotel and were sent up to our room. A little later, we pulled the cover off the bed and rolled back the blankets, and BOTH sheets were soaking wet. I'll leave the rest to the reader's imagination but will note that it was a sticky bodily fluid, and not urine.
Our entire weekend was comped.