The Sharp Edge is new to me also. I'll try it next time I'm in town.

Whenever I get into town, I always try to make it to Fatheads (Carson St on the South Side). For my money, this is the best food/beer deal in the 'burgh. They have about 40 beers (~75% imports) on draft and lots of bottles. The sandwiches are huge, excellent and cheap. I'm not a chicken wings fan, but they get very high marks on these. Go hungry and skip the appetizers. If you haven't been there in a while, they have doubled their space which is a great improvement.

For other folks who aren't familiar with Pittsburgh, they might enjoy:
-riding the incline to the top of Mt Washington
-walking the Strip District on Saturday AM for the shopping experience
-cruising the Strip District at night for the club action
-Kennywood as previously mentioned
-classrooms at the Cathedral of Learning

any other ideas?