I have to take Meclizine to avoid motion sickness when flying. I take it around an hour before we take off so that it is working on time. I cannot take Dramamine or Benadryl (same ingredient) because they stimulate me.

Meclizine doesn't make me sleepy, but can dry you out, so be certain to drink a lot of fluids.

I would try any medications in advance of your trip to be certain of potential side effects.