The only way to simulate that would be a vacuum chamber.

The lowest cabin pressure you will see in normal conditions in a commercial aircraft is an equivalent effective cabin altitude of about 8000 ft when the aircraft is at 40,000 ft cruise... This is not common.

You will normally see a cabin altitude of between 5000 and 6900 ft depending on cruising altitude and what equipment you are flying in.

Most people can easily tolerate an equivalent effective cabin altitude of 8000 ft. In general, only people with compromised lung or heart function should worry about going above 5000 ft.