Thank you all for you comments.

Just to close out this post and to provide information for anyone that follows with a search. We checked out those offered here and Princess Pacific, Oceania Regatta, Holland Masdam and Princendam, Seabourn Sojourn and Regent Mariner Silverseas-silver Cloud and Crystal.

We ended up on Regent. They were tied for most expensive, but all inclusive. Our deal included air, one precruise night hotel w/breakfast, all liquids aboard (you can pay more for extra quality), all tips, all tours (again you can pay more for premium tours), transportation between AP and hotel and ship and then from ship to AP at the end. We booked with Pam Tafoya at Palvus travel for a nice discount and some shipboard credit. They have a referral program if anyone is interested they can private message me, or just call her for a comparison quote. The cruise is in Feb of 2013, therefore it does not interfer with the holidays and lines up well with our anniversary (38th?). Regent seems first class in all respects. They also seem to have a bit more relaxed dress code than some of the other cruise lines considered.

Crystal matched the high end pricing and quality comments. We dropped them purely on the basis of the comments we read. They seem to be a more dressy and formal (caviar, tuxes, even daily attire) line that we are interested, and we felt we would not fit in.

Seabourn was in the analysis to the end. Only a little less inclusive. Even after we adjusted for tours, pre cruise hotel and 2 nights of cruise length, it was still a better buy than Regent...with my flaky analysis. Something about Lisa at Regent, what Pam felt about Regent and some itenery issues. You have to fly out of Manaus on Seabourn...seemed like a crazy and lengthy trip. We liked the termination of Regent trip in Miami.

Holland is a solid cruise line. We have over 75 nights with them. We were not picked up at the airport on one cruise, though booked with HAL. Took a bunch of levels and discussions to get reimbursed our costs. We we upgraded once to a cabin that had a huge balcony (stern) that had a deep depression. The furniture rocked and rolled. The "hole" filled with water daily. A few days in the crew varnished the railing using our cabin as base. They spelled a gallon of varnish outside our door which filled our room with fumes. It took 5 hours to get someone to do something about it, and two days breathing those fumes with equipment running before we got moved to another cabin. Naturally we could not use the balcony anymore either. So they do a good job when things go well, but are bad about handling problems. The iteneries were great for the Amazon, but both the cruises were longer..26 and 32 days. HAL also has a way of overpricing everything, and being cheap on inclusives. Tour handling is bad, and the drivers of the tenders have no training...unsafe (Med. cruise).

Princess is a down scale cruise line compared with this list and was only 14 days. It also started Jan 3rd, making travel over NY likely. They also included flying into Manaus.

Silverseas has mixed reviews, but would have been in the running except they include Thanksgiving in the time frame. Mom is 92, so I am not missing those special days with her. They also have a broadly divergent set of comments by passengers.

Oceania Regatta has small cabins and issues until you get to the consierge (sp) level (no refrig.). Their cruise dates went into April making tax time a bit of a balancing act. They we a bit more wallet friendly.

Note on these cruises (if US citizen) you will need a Brazilian Visa (plan ahead) and likely a yellow fever shot. Manaus is a huge city (pop). Many of the ports served a tiny, with modest tours, except for private car/van.