Hello everyone

I am a complete noob to the frequent flier world (I've traveled a lot but never bothered to pay attention to the flyer mile system since my parents booked everything/we always looked for cheapest deals).

I'm going to be a strategy consultant, meaning I'll be traveling Mon-Thurs every week. With that in mind, I'm thinking that an airline that has a large national presence would be best as I would most likely be able to use that airline regardless of client locations (which could be in random areas).

I'm also trying to balance that with the best perks for frequent fliers. With those factors in mind, which airlines do y'all recommend? It'd be much appreciated!