Would this card be limited solely to the minor business expenses when AMEX isn't accepted? What about putting your regular daily personal spending on the same card? I'm assuming this will be a personal card that you apply for, and then would get reimbursed personally from the company. AMEX is probably going to be accepted most places you go, so the spend on your other card will probably be very small and not justify an annual fee. However if you decided to transfer over all of your regular personal spending to that card, it opens up more options where a card with a higher annual fee might be the best choice.