This question is impossible to answer without more details about you, where you live, your travel habits, your favoured airlines (just because you don't stick to one doesn't mean you don't like one in particular) and what is important to you from the FFP. From the extremely limited information you gave us, a Oneworld programme (either AA or LA) seems likely to be suitable for you, since AA covers pretty much all of the regions you described and LA is huge in South America.[/QUOTE]
You need to find the Alliance that best suits you and then sign up for one of the Air Lines in that Alliance. But like some one said if you fly on another Alliance sign up for a FF program, it's free. In todays world you have to look at Alliances more than a single Airlines. Good luck.