Staying sane:
Take some photos of people who love you and put them in your hotel room. I put a snapshot of my husband right next to the hotel phone where I will see it when I first wake up.
My father did a lot of business travel, and he had one inviolate rule: Never drink (alcohol) alone.
He would have a drink, or two, in the company of a business companion or co-worker, or with my mother, but never would he drink alcohol when he was by himself. My father's father was an alcoholic, as was my mother's father. Both my parents were rigid about drawing boundaries around their personally-allowed drinking.
I never drink alcohol, and I believe that is one of the reasons I do well with international travell. I have minimal jet lag, always a clear head and am not tempted to do things I should not do.