Last week I made an award ticket change on the return portion of a ticket. The agent was able to hold the outbound segment.
The return had a stopover and the agent was able to hold the long-haul flight, while giving me options to change the time of the short-haul flight.
So I believe they can hold award inventory while making these minor changes.
In my account, the activity showed as a re-deposit of miles and then a re-issue.