Was at SYR last Friday..... had 6am flight out FRiday morning.... when I flew-in on Thursday afternoon, spoke with TSA three-striper supervisor at the Delta/United concourse who said at least 90 mins ahead (4:30am for 6am flight).....120 mins if you are checking a bag at the airline counter......that sounded silly, but spoke with Delta ticket counter at SYR who said the same.
Looking at the departure screens for Frisday morning...it did make some sense....every airline has a flight out between 5:45am and 6:30am to each their hubs.....for example, DL has 5:45am to JFK, 6am to DTW, 6:30 to ATL.
FYI--Holiday Inn Express and one of their Suite properties are closest to airport....no stoplights, no getting on/off highway, so easiest for me at 4:30am!!!!