<font face="Verdana, Arial, Helvetica, sans-serif" size="2">Originally posted by imad:
3 - minimize total trip length (I'd gladly do it under the 10 day minimum that RTW requires, if I could)
4 - and of course, more Q-miles/Q-points wouldn't hurt...
</font>
If you want to do the whole thing in the minimum 10 days I think it boils down to a choice between time in the four cities you list or time on planes to get more miles. You can easily get at the very least another 20,000 flown miles out of a 4-continent OWE RTW but it comes at the expense of your four stops becoming quite brief.
<font face="Verdana, Arial, Helvetica, sans-serif" size="2">
Would a westbound route be better?
</font>
Eastbound cuts the flying time due to prevailing winds, but IMHO westbound is better jetlag-wise.