My home airport is TLH, and every single flight I have _ever_ taken out of TLH has involved a transfer at either ATL or CLT--a quick check on TLH's online departure board shows, among the next 10 departures (across 6 hours; not a very busy airport), 5 to ATL, 2 each to CLT and TPA, and 1 to DFW.

If a TDC at TLH asks me where I'm going, I'll have no problem telling them where I'm going: "Charlotte!". Just like about one-fifth of all the passengers going through the TDC. :-)