Originally Posted by
adventureadam
agreed with above that it's hard to point you in the right direction without knowing anything about you or what your interests are while traveling.
That said, if you're going during decent weather, I think there's little better way to see Prague than through it's parks, particularly Letna, Riegrovy, Petrin, and Vysehrad.
Adam - I tripped over Vysehard totally by mistake. It was really quite interesting. I picked a stop off the subway away from the center, and that was the last stop shown on my map, so I got off at that one.