Greetings from the CSA Crystal Lounge at PRG. Finding Airport Express at the main railway station (or getting to the main railway station from Cafe Imperial for that matter) was not as straightforward as I thought. I know I should have consulted a map but thought I could just follow my nose.
A kind security guard outside a shop at the railway station escorted me all the way to the Airport Express bus stop which is two levels up and not at all obvious if approached from the centre or Masarykovo Nadrazi. Not sure if it's easier if you arrive by metro.
But once you are on the bus, it's quick and very straightforward and I can thoroughly recommend it.