I guess I'm a loner.. On 130 flights this year I've only chatted it up with two other people except my wife on the flight... that was one of the few times I was in the last row of a plane, in the aisle, across from another guy in the aisle. We were both in pain since we couldn't recline and the jerks in front of us were reclining the whole way, so we chatted it up.
The other time was when my flight was cancelled and I was re-routed and I noticed the girl sitting next to me was on the same re-route. She was probably one of the prettiest girls I've sat next to, but I try to convince myself and my wife that had NOTHING to do with it

It might also be since she's one of the few people I've ever sat next to that is within 10 years of my age!
If someone tries to strike up conversation with me I usually answer politely and then let it drop..
When I am in the city I try to find new places to eat that I can not find in my home town and check out the location of touristy places. Normally I don't have time to visit those places but I keep them in mind if my wife and I take a leisure trip there in the future...