The Mileage Monkey tool will tell you if your proposed route complies with the Oneworld Explorer rules. Type your route into its Oneworld Explorer Validator box.

For a DONE5 itinerary, you will have to decide which of the six continents to leave out. Since you want to visit JFK, EZE or SCL and TYO and you are starting from Europe - that means leaving out either Africa or the South West Pacific.
If you are wanting to maximise miles - I expect it would be better to leave out Africa. Then you can make use of the rule exceptions that allow two visits to Nth America and Asia with a routing such as EZE-JFK-NRT-SYD (which of course takes many more miles than flying EZE-SYD non-stop)