There is a really cool/gross museum at 22nd and about Chestnut - a cab ride from where you are - called the Mutter (with an umlat (sp?) over the "u" - which is in the basement of the college of physicians - medical oddities - 100,000s of items that people have swallowed, a plaster cast of the liver of the original Siamese twins, and other weird stuff.
For the more pedestrian tastes - there is a tour of City Hall (the big wedding cake-shaped building in the center of downtown) every day at about noon, the historic district - Ben Franklin, Betsey Ross, Liberty Bell - is within walking distance of your hotel. Enjoy!!