It doesn't matter whether it's interstate or not: the argument is that aviation is a Federal matter. If you're arrested on Federal drug charges, proving that the drugs were always within your state isn't a defense.

But it's not at all clear that supremacy would apply here or in what form. The classic case is where a locality passes a law that dictates flight paths. The FAA then argues (successfully) that they aren't bound by such a law.

Here, it's different because it's a criminal matter involving an individual that's clearly under the jurisdiction of the state. There's not a whole lot of precedent in a situation like that.