If you want a Hilton property to stay at, I stay at the HGI in chelsea a lot. Close to a lot of action and a half block from the 1 line that will take you to 50th street if you want to go to the HK bars or Christopher street if you don't want to go out in Chelsea. I also like the HGI on 8th a lot IF I can get a good rate, the breakfast there is the best I have ever had at an HGI, it's near the hells kitchen bars, close to the theaters and by the 1 line and the 8th street subways and lots of places to eat.
If you want to use Hilton points then I would recomend the Double Tree on Broadway, GREAT hotel to use HH points at. Excellent location and all suites and GREAT breakfast buffet for Diamonds.