I am heading (back to Prague) in a couple weeks and was doing some check. I had not seen this post last time I went and thought it would be a help to others.

Take the advice of others on here and get out of the city center if you have time. If you are doing what most Americans do where you go to a city to see it as fast as you possibly can, you can get away with that is other Eastern European towns, but there is so much to do here, it will really do you an injustice to just do 2-3 nights here. Some of what I enjoyed the most was taking local transportation out to the suburbs and enjoying the better prices and very kind people. I even got a nice pair of Ecco shoes for $30 US last year at an outlet mall at the end of the metro line.