I do not believe there are any written restrictions per se... I mean not something similar to what is in oneWorld RTW fare rules, that if your itinerary includes Cuba, you cannot have any AA segment in the entire ticket... At least I have never seen anything similar for TLV and Saudi Arabia... But there is another rule for them: they will not let you in, if your passport includes any Israeli boarder/immigration stamp... And even if you do not have any Israeli stamp (you can ask Israeli immigration folks to put it on a separate piece of paper), your itinerary will be so unusual, they might detect you actually fly from Israel and deny entry... It might work for JED/RUH-TLV though