yup.
The issue really come in if you have internet access or not.
For me when I'm on the ground I always have internet. Be it at home with my cable modem and wireless/wired network, or on the road with my android phone (3g mobile hotspot) or my data sim and portable battery powered UMTS router or my netbook that has built in UMTS. For files I use every day, it's just easier to do it via the web as everything gets synced.
But for large files, videos, etc the flash drive is just more practical. faster than online syncing (I mean like 1gb+ files) and also less internet use (for the limited mobile providers).
It depends on what you are doing, but web based syncing seems to be quite good and with so many options (dropbox, sky drive, etc) it's nice and easy