You didn't say a thing about who has more flights (especially non-stop) / better schedules to your future destinations from DEN. That is where you should start your analysis.

Will you fly mostly long-haul or short-haul?

You say first is not permitted, but don't mention whether Business Select is permitted.

How do you define "Road Warrior?" An extreme road warrior won't find it necessary to put all his eggs in one basket, whereas a light road warrior might find doing so advantageous.

What is your family situation?

What do you want to do with the FFP benefits you accumulate?