Thanks for the useful input. Quieter drive, Helen Keller's birthplace (didn't realize where she lived; I think my wife would particuarly enjoy seeing it) and another state on my list. Sounds like 72 may be the way. If we spend the night in Fayetteville, Tennessee rather than Lynchburg (since we may do tours just the next day, and one of two distilleries we want to go to-- Prechards--is in Kelso, closer to Fayetteville), Google Maps shows the quickest route after Keller's place to be up I-65, but going through Huntsville and then "smaller" highways is estimated at just 9 minutes longer. Hoping that we won't hit big crowds once we get to the Jack Daniel's distillery, sínce it'll be mid-February, and a weekday.