Consider Pittsburgh. In a weekend you can visit the Warhol Museum, the Carnegie Museum of Art/Natural History and if you have kids, the Pittsburgh Children's Museum is world class. There is also the Carnegie Science Center and numerous other places to visit. You could even rent a car and drive into the countryside to see Frank Lloyd Wright's Falling Water. Depending upon the season go to a sporting event. Take the incline up Mount Washington at night. Falling Water is beautiful in the autumn.