Did Rome to port via train...
DD and I did it via the train, and maybe we're just "sports" but we found it easy... But I have champagne taste on a beer budget, so in order to afford the travel I want, I have to make $$$ concessions in certain areas. Shlepping our bags on trains vs. paying for transfers is one of those areas. It also helps that I (we) travel very light. One bag each, plus a big purse type bag. That was for 16 nights in Europe.