Do not, I reperat do not stay at the Maritim Hotels!!! I'm on a project in Darmstadt since April and tested all the larger hotels in Darmstadt.
The best hotel is the Welcome Hotel
Welcome Hotel Darmstadt. The hotel is new, modern, clean and has very good service. It is located right in the middle of Darmstadt and you get every where very easy. Are you traveling on company expanses? The Welcome Hotel has for many companies which are located in Darmstadt like Merck, Deutsche Telekom special rates. So ask them if they have special rates.
If the Welcome Hotel is booked try the Ramada. It is clean and the staff is very careing.
The Maritim Hotles on the other are expansive and in bad shape.
If you have a car there are a few other hotels which are outside of Darmstadt. The NH Mörfelden-Frankfurt and the Holiday Inn are okay but you need a car. The last alternative would be staying in Frankfurt close to Central station and taking the Train to Darmstadt in the morning. Takes about 20 minutes.
If you have any questions about Darmstadt, feel free to contact me by PM.