Understand that david, but I think if someone comes looking for advice and the best advice is to change their plans, it's ok to say that.
In my opinion, this is too much to do in too few days. In my opinion, driving is a really bad idea...to say nothing of driving through the Alps at night in the middle of winter after getting off a plane, Prague is usually congested during the day. Parking is nearly impossible in the middle, unless the hotels offers it, in which case it will be quite expensive. If the OP insists on seeing all of these places in a short amount of time, train travel seems far preferential because it will greatly reduce stress, make things much easier, save a lot of money, and will allow him to actually interact with humans in a relaxing atmosphere instead of isolating himself in a stressful situation.
Just my opinion.