Of course. I only gave an extremely simple and hypothetical example to show the principle. There are normally of course many other complex calculations done first to cater for all sorts of different conditions before you get to the the last part of the ultimate fail value being divided by the design max value. But that ratio is still valid as the very final part of the calculation to derive the "safety factor" number.

And to use your Fahrenheit and Kelvin examples.....there are of course codes of practice and numerous regulations as to which measurement parameters are used...to prevent the best case always being used