Originally Posted by Driving by DCA

I would say the Grand if you are going to us a suite upgrade because it's upgrade rooms.

Other than that, in my experience, there's not a ton to choose from between these two. They're a quick walk from each other and each has easy access to the 16th Street Mall/LoDo/Capitol Hill/etc.

I tend to find the Grand slightly better at the upgraded room levels.

The other thing to keep in mind is that the Regency is the Denver Convention Center hotel and can get swamped with convention guests while the Grand tends to have, at most, smaller meeting groups. Whether one or the other situation is better or worse is a matter of personal preference.