I'm relatively new to cruising. I sailed on the Celebrity Solstice in April '10 and the Celebrity Summit in July '10. During rare rough periods, the swaying, occaisonal quick vibrating bumps and looking out the window seeing the waves never bothered me night or day. Both cruises were overwhelmingly calm. Its just like a giant, moving hotel building that you get used to.
It was strange but I had no symptoms - until the cruises were over and I was off the ship! Then I would feel nauseous. I would see walls inside and buildings outside swaying due to my brain still thinking it was on a ship. It took about 24 hours after the cruise ended for the symptoms to go away.
So for some, the seasickness happens after the good times are over!