I do market research in emerging markets. From mid-july until the end of October I will fly 105,000+ miles. I wouldn't trade the work, but we all have limits. I did 40K last month in the air, 2K by train. (only the ORD-PEK was in business) I was in a plane or train 22 out of 23 days. At one point I had to fly Tokyo to my home in Kentucky for 14 hours and then get on a plane back to Beijing.
I typically will try to spend at least 1 day to sight see on these trips so that it my bonus. I couldn't do it if I had a family,