An article on the Mail Online's website reports on a QF pax going a bit bonkers; running down the aisle screaming "You're all going to die!" and trying to open an emergency exit door while in flight. Of course he couldn't open the EE door (I say just leave these people alone, they won't be able to open the door and they'll wear themselves out eventually

) and was subdued by crew members.
According to the article, a PE pax said that: 'There was one lady that was quite upset. She moved into our cabin in Premium Economy because she said "I heard too much, I heard too much - I can't go back down there [into the main part of the cabin]".'
I'm not sure that I would have the presence of mind to upgrade myself in such a situation but, clearly, there's no "off" position on the genius switch!