Fresno leaves most of the drive for the second day. (roughly 90 of 400 miles)

I'd think about Bakersfield... (roughly halfway)

Can't say as I think of either town much for it's nightlife... Which I'd associate with Los Angeles or SFO, but doubtless you should be able to find a bar or club w/ live music in either.

Try Yelp.com and search for "[community name] nightlife"