I would say no. Interstate 5 from Seattle to Portland is a grim, congested, mostly featureless slog. Avoid or take Amtrak.

Instead... my favorite drives in the US would be:

** US101 around the Olympic Peninsula, especially Crescent Lake west of Port Angeles

** Vermont Route 100 south of Waitsfield, particularly this time of year when the leaves are turning

** Interstate 93 / 91 from Concord, NH to the Canadian border

** Another vote for California 1 through Big Sur, Monterey to SLO -- that's the dramatic coastline you want

** South Dakota Route 240 south of Wall, through the Buffalo Gap National Grassland... incredible

** The road through Joshua Tree National Park in California, south of Twentynine Palms

** The loop road around Acadia National Park in Maine (have to disagree with the poster upthread about the Maine coastal road though... US Route 1... badly maintained two-lane blacktop, bumper to bumper in summer, not many ocean vistas)

** The Blue Ridge Parkway in Virginia